The prototype (PH-AJR) flew in early 1935 and was followed by two production machines, accommodating 22 passengers. All three were delivered to KLM, the prototype in March and the other two in May 1935. One aircraft crashed on 14 July 1935, but the other two operated European routes until they were sold in the UK, PH-AJR becoming G-AFXR in August 1939 on joining British American Air Services, and PH-AJP being re-registered G-AFZP in the following month when it was acquired by Scottish Aviation. Impressed for RAF service as HM159 and HM160 in October 1941, the two aircraft were used for transport and crew training. HM159 caught fire in the air and was lost in the Highlands, but HM160 was returned to Scottish Aviation post-war under its previous civil registration. It flew between Prestwick and Belfast for a time before being grounded finally at the end of 1947.
A fourth F.XXII was built for Swedish AB Aerotransport and delivered in March 1935. Named Lappland, it flew a regular schedule between Malmo and Amsterdam until destroyed in an accident at Malmo in June 1936.
Engines: 4 x Pratt & Whitney Wasp T1D1 radial, 373kW
Max take-off weight: 13000 kg / 28660 lb
Empty weight: 8100 kg / 17858 lb
Wingspan: 30.00 m / 98 ft 5 in
Length: 21.52 m / 70 ft 7 in
Height: 4.60 m / 15 ft 1 in
Wing area: 30.00 sq.m / 322.92 sq ft
Max. speed: 285 km/h / 177 mph
Cruise speed: 215 km/h / 134 mph
Ceiling: 4900 m / 16100 ft
Range: 1350 km / 839 miles
Passengers: 22
All Aero 